The Downstream Processing Market Will Grow At Highest Pace Owing To Rising Demand For Vaccines Production

 
Downstream Processing Market 

The downstream processing market involves separation, purification and recovery of biological products from fermentation broth. Downstream processing helps in extracting and purifying products such as monoclonal antibodies, recombinant proteins, vaccines, hormones, culture media and antibiotics from fermentation broth. Several steps are involved in downstream processing such as concentration, washing, centrifugation, chromatography, formulation and storage. Key advantages of downstream processing are thorough purification of final products from contaminants, facilitating cost-effective manufacturing and consistent quality improvement. With the growing emphasis on vaccine manufacturing for infectious diseases, downstream processing market is witnessing high demand.

The Global Downstream Processing Market is estimated to be valued at US$ 246.2 Mn in 2024 and is expected to exhibit a CAGR of 2.6% over the forecast period 2024 to 2031.

Key Takeaways
Key players operating in the downstream processing market are Merck KGaA, Thermo Fisher Scientific Inc., GE Healthcare, Sartorius Stedim Biotech S.A., Repligen Corporation, Pall Corporation, M Company, Eppendorf AG, Agilent Technologies, Inc., Waters Corporation, Shimadzu Corporation, Bio-Rad Laboratories, Inc., Avantor Performance Materials, LLC, Tosoh Corporation, Column Technology Inc., Purolite, W.R. Grace & Co., Asahi Kasei Corporation, Novasep Holding S.A.S, and Boehringer Ingelheim. Merck KGaA dominates the downstream processing market with highest market share owing to its comprehensive downstream processing technology portfolio.

The increasing demand for biological drugs for treatment of chronic diseases and rising government emphasis on vaccine manufacturing is expected to surge the demand for downstream processing. According to a report, global COVID-19 vaccine manufacturing capacity is expected to reach 24 billion doses by 2023. This will drive significant growth in Downstream Processing Market Demand.

Technological advancements in downstream processing equipment such as use of single-use technologies, improved column chromatography resins, acoustic separators and automated analytical systems are leading to enhanced efficiency, cost-effectiveness and higher throughput. This will augment the downstream processing market size during the forecast period.

Market Trends
Some key trends in the downstream processing market include:

- Growing preference for single-use technologies: Single-use technologies facilitate on-demand manufacturing, lower equipment requirements and lower risk of cross-contamination. Their adoption is increasing rapidly.

- Automation of operations: Technologies enabling automated liquid handling, chromatography control and automated validation are being adopted to enhance throughput, reproducibility and operational consistency.

- Continuous manufacturing: Continuous manufacturing is gaining prominence as it provides higher yields than batch manufacturing. Continuous chromatography and continuous tubular mixer settlers are key technologies.

Market Opportunities
The key opportunities in the downstream processing market are:

- Cell and gene therapy manufacturing: Growing cell and gene therapy clinical pipeline will drive significant demand for improved purification technologies in downstream processing.

- Biopharmaceuticals for emerging markets: As biopharmaceutical access increases in emerging Asian and Latin American countries, local manufacturing capacities are being enhanced through partnerships. This offers significant opportunities.

Impact of COVID-19 on Downstream Processing Market

The COVID-19 pandemic has significantly impacted the growth of the downstream processing market. Due to lockdowns imposed across various countries, disruptions were caused across biotech and pharmaceutical supply chains. This led to delays in new product launches and reduced capacity utilization of manufacturing facilities. Additionally, travel restrictions made it difficult for companies to transport raw materials and finished products. The lockdowns also resulted in temporary shutdowns of several R&D and manufacturing facilities, negatively impacting the demand for downstream processing products in 2020.

However, with vaccination drives picking up pace globally, production and supply chain activities are recovering fast. There is renewed focus on developing vaccines and therapeutics for COVID-19, boosting the demand for downstream processing. Companies are ramping up their production capacities to meet the surge in demand. The pandemic has also highlighted the need to enhance preparedness for health emergencies. This is encouraging investments in building and expanding manufacturing infrastructure, which will drive growth opportunities for downstream processing vendors. Several countries are providing funding and tax incentives to boost domestic bioproduction, which will further aid the market recovery. The long-term impact of COVID-19 is expected to be positive as it has catalyzed investments in healthcare infrastructure and drug development globally.

North America holds the largest share of the downstream processing market in terms of value. This is attributed to presence of several global players, rising biopharmaceutical R&D expenditure, and rapid adoption of advanced technologies. Europe is another major region concentrated with downstream processing companies due to increasing focus on healthcare. Asia Pacific is poised to be the fastest growing regional market, driven by rising biologics production in countries like China, India, and South Korea. Government support in the form of investments and favorable business policies will continue fueling growth opportunities across APAC.

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About Author:

Ravina Pandya, Content Writer, has a strong foothold in the market research industry. She specializes in writing well-researched articles from different industries, including food and beverages, information and technology, healthcare, chemical and materials, etc. (https://www.linkedin.com/in/ravina-pandya-1a3984191)

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